The clashes erupted when Tel Aviv armed forces raided the Qusra village south of Nablus and faced the resistance of angry residents, a Palestinian official said.
The Israeli soldiers used live bullets against the protestors and shot one Palestinian twice and left him in critical conditions. Another protester was hit with rubber coated metal bullets used to disperse the crowd.
There was no report on the condition of the two other injured Palestinians.
Another clash erupted near Israeli Tekoa illegal settlement north of al-Khalil (Hebron).
Tel Aviv forces used tear gas against the crowd leaving dozens of Palestinians with excessive breathing problems due to inhalation of tear gas.
The occupied Palestinian territories have witnessed new tensions ever since Israeli forces imposed restrictions on the entry of Palestinian worshipers into the al-Aqsa Mosque compound in East Jerusalem al-Quds in August 2015.
Nearly 240 Palestinians have lost their lives at the hands of Israeli forces in the tensions since the beginning of last October. The violence has also killed at least 32 Israelis, two Americans, an Eritrean and a Sudanese.